Relation of Particle size with Toxicity of Calcite Particles

Authors

  • H. N. Sharma Department of Environmental Toxicology, School of Life Science, Dr. B.R. Ambedkar University, Agra-282002.
  • Asna Baig Department of Environmental Toxicology, School of Life Science, Dr. B.R. Ambedkar University, Agra-282002.
  • Madhuri Dixit Department of Environmental Toxicology, School of Life Science, Dr. B.R. Ambedkar University, Agra-282002.
  • Iqbal Ahmad Fibre Toxicology Division, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
  • Shivani Verma Department of Environmental Toxicology, School of Life Science, Dr. B.R. Ambedkar University, Agra-282002.
  • Prashant Kumar Department of Environmental Toxicology, School of Life Science, Dr. B.R. Ambedkar University, Agra-282002.

Keywords:

Nanoparticles, Clay particles, Chemical properties, Particle size

Abstract

The importance of certain types of nanomaterials and mineral nanoparticles, namely clays and the smallest mineral colloids, has been known for a long time. Mineral nanoparticles also behave differently than larger micro and macroscopic crystals of the same mineral. The variations in chemical properties are most likely due to differences in surface and near surface atomic structure, as well as crystal shape and surface topography as a function of size in this smallest of size regimes. Although most of the nanotoxicological studies were performed using unrealistic exposure conditions. Knowledge about potential human and environmental exposure combined with dose response, toxicity information will be necessary to determine real or perceived risks of nanomaterials following inhalation, oral or dermal routes of exposure. Because the respiratory tract is the major portal of entry for airborne nanoparticles, this exposure route can be used as an example to discuss some key concepts of nanotoxicology, including the significance of dose, dose rate, dose metric and biokinetics.

Downloads

Download data is not yet available.

References

Brown, D.M., Wilson, M.R., MacNee, W., Stone, V. & Donaldson, K. (2001). Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol., 175(3): 191–199. https://doi.org/10.1006/taap.2001.9240.

Donaldson, K., Li, X.Y. & MacNee, W. (1998). Ultrafine (nanometre) particle mediated lung injury. J. Aerosol Sci., 29(5): 553–560. https://doi.org/10.1016/S0021-8502(97)00464-3.

Ellenhorn, M.J. & Barceloux, D.G. (1998). Ellenhorn’s Medical toxicology: Diagnosis and treatment of human poisoning. 2nd edn, Lippincott Williams and Wilkins, Baltimore, MD.

Gilmour, P., Brown, D.M., Beswick, P.H., Benton, E., MacNee, W. & Donaldson, K. (1997). Surface free radical activity of PM10 and ultrafine titanium dioxide: A unifying factor in their toxicity? Ann. Occup. Hyg., 41(Suppl. 1): 32–38.

Kampalath, B.N., McMahon, J.T., Cohen, A., Tomashefski, J.F., Jr, & Kleinerman, J. (1998). Obliterative central bronchitis due to mineral dust in patients with pneumoconiosis. Arch. Pathol. Lab. Med., 122(1): 56–62.

Lin, W., Huang, Y.W., Zhou, X.D. & Ma, Y. (2006). In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol. Appl. Pharmacol., 217(3): 252–259. https://doi.org/10.1016/j.taap.2006.10.004.

Matés, J.M., Pérez-Gómez, C. & Núñez de Castro, I. (1999). Antioxidant enzymes and human diseases. Clin. Biochem., 32(8): 595–603. https://doi.org/10.1016/s0009-9120(99)00075-2.

Nel, A., Xia, T., Mädler, L. & Li, N. (2006). Toxic potential of materials at the nanolevel. Science, 311(5761): 622–627. https://doi.org/10.1126/science.1114397.

Oberdrster, G. (2000). Toxicology of ultrafine particles: in vivo studies. Philos. Trans. R. Soc. London, Ser. A, 358(1775): 2719–2740. https://doi.org/10.1098/rsta.2000.0680.

Oberdorster, G. (1996). Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles. Inhal. Toxicol., 8 Suppl: 73–89.

Oberdörster, G., Ferin, J., Gelein, R., Soderholm, S.C. & Finkelstein, J. (1992). Role of the alveolar macrophage in lung injury: studies with ultrafine particles. Environ. Health Perspect., 97: 193–199. https://doi.org/10.1289/ehp.97-1519541.

Oberdorster, G., Gelein, R.M., Ferin, J. & Weiss, B. (1995). Association of particulate air pollution and acute mortality: involvement of ultrafine particles? Inhal. Toxicol., 7(1): 111–124. https://doi.org/10.3109/08958379509014275.

Oberdörster, G., Oberdörster, E. & Oberdörster, J. (2005). Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect., 113(7): 823–839. https://doi.org/10.1289/ehp.7339.

Osim, E.E. & Esin, R.A. (1996). Lung function studies in some Nigerian bank workers. Cent. Afr. J. Med., 42(2): 43–46.

Wang, X., Yano, E., Nonaka, K., Wang, M. & Wang, Z. (1997). Respiratory impairments due to dust exposure: a comparative study among workers exposed to silica, asbestos, and coalmine dust. Am. J. Ind. Med., 31(5): 495–502. https://doi.org/10.1002/(sici)1097-0274(199705)31:5<495::aid-ajim2>3.0.co;2-t.

Downloads

Article Metrics

Abstract Views: 215
PDF Downloads: 70

Published

2014-01-01

How to Cite

Sharma, H. N., Baig, A., Dixit, M., Ahmad, I., Verma, S., & Kumar, P. (2014). Relation of Particle size with Toxicity of Calcite Particles. Advances in BioScience, 5(1), 7–11. Retrieved from https://journals.sospublication.co.in/ab/article/view/142

Issue

Vol. 5 No. 1 (2014): January

Section

Articles

License

Copyright (c) 2014 The author(s) retains the copyright of this article.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Most read articles by the same author(s)

1 2 > >>