Assessment of Immunotoxic response in Albino Rats following Nickel Nitrate Treatment

Authors

  • Prabhu N. Saxena Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002, U.P., India.
  • Reena Yadav Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002, U.P., India.

Keywords:

Nickel nitrate, Albino rats, IgG, DLC, Granulocytes

Abstract

Nickel nitrate affects body physiology and immunology following its absorption through food, water, air. Predetermined doses of nickel nitrate (Ni(NO3)2] in acute (1 d) and subacute (7, 14, 21 ds) treatments revealed a significant increase in IgG concentration and lymphocyte number, whereas, neutrophils and eosinophils registered significant fall. These alterations indicated heavy metal stress in Immunological parameters that become targets.

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References

Agency for Toxic Substances and Disease Registry (ATSDR) (1997). Toxicological profile for nickel (updated). Public Health Service, U.S. Department of Health and Human Services, Atlanta, G.A.

Barceloux, D.G. (1999). Nickel. J. Toxicol. Clin. Toxicol., 37(2): 239–258. https://doi.org/10.1081/clt-100102423.

Finney, D.J. (1971). Probit analysis. 3rd edn., Cambridge University Press, 333 pp.

Flyvholm, M.A., Nielsen, G.D. & Andersen, A. (1984). Nickel content of food and estimation of dietary intake. Z. Lebensm. Unters. Forsch., 179(6): 427–431. https://doi.org/10.1007/BF01043419.

Gawkrodger, D.J., Lewis, F.M. & Shah, M. (2000). Contact sensitivity to nickel and other metals in jewelry reactors. J. Am. Acad. Dermatol., 43: 31–36. https://doi.org/10.1067/mjd.2000.107235.

Haber, L.T., Erdreicht, L., Diamond, G.L., Maier, A.M., Ratney, R., Zhao, Q. & Dourson, M.L. (2000). Hazard Identification and Dose Response of Inhaled Nickel-Soluble Salts. Regul. Toxicol. Pharm., 31(2): 210–230. https://doi.org/10.1006/rtph.2000.1377.

Jadhav, S.H., Sarkar, S.N., Ram, G.C. & Tripathi, H.C. (2007). Immunosuppressive effect of subchronic exposure to a mixture of eight heavy metals, found as groundwater contaminants in different areas of India, through drinking water in male rats. Arch. Environ. Contam. Toxicol., 53(3): 450–458. https://doi.org/10.1007/s00244-006-0177-1.

Melik, D.H. & Fogler, H.S. (1983). Turbidimetric determination of particle size distributions of colloidal systems. J. Colloid Interface Sci., 92(1): 161–180. https://doi.org/10.1016/0021-9797(83)90125-X.

Nielsen, G.D., Søderberg, U., Jørgensen, P.J., Templeton, D.M., Rasmussen, S.N., Andersen, K.E. & Grandjean, P. (1999). Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity. Toxicol. Appl. Pharmacol., 154(1): 67–75. https://doi.org/10.1006/taap.1998.8577.

Roitt, I., Brostoff, J. & Male, D. (1996). Immunology. Dianne Zack, 4. izdaja, London.

Salnikow, K., Li, X. & Lippmann, M. (2004). Effect of nickel and iron co-exposure on human lung cells. Toxicol. Appl. Pharmacol., 196(2): 258–265. https://doi.org/10.1016/j.taap.2004.01.003.

Von Burg, R. (1997). Toxicology Update: Nickel and some nickel compounds. J. Appl. Toxicol., 17(6): 425–431. https://doi.org/10.1002/(SICI)1099-1263(199711/12)17:6%3C425::AID-JAT460%3E3.0.CO;2-R.

Wintrobe, M.M. (1981). Clinical Haematology. 8th ed., Philadelphia: Lea & Febiger.

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Published

2014-07-01

How to Cite

Saxena, P. N., & Yadav, R. (2014). Assessment of Immunotoxic response in Albino Rats following Nickel Nitrate Treatment. Advances in BioScience, 5(3), 83–85. Retrieved from https://journals.sospublication.co.in/ab/article/view/152

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Vol. 5 No. 3 (2014): July

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Articles

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