Toxicity Assessment of Nickel Nitrate and Effect on Total Leucocyte Count in Albino Rat

Authors

  • Reena Yadav Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002, U.P., India. http://orcid.org/0000-0003-2208-4500
  • P. K. Singh Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002, U.P., India.
  • Neelam Upadhyay Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002, U.P., India. http://orcid.org/0000-0001-8004-7543

Keywords:

Toxicity Assessment, LD50, Nickel Nitrate, TLC, Albino Rat

Abstract

Heavy metals contribute a variety of adverse health effects. There are over 20 different heavy metal toxins that can impact health effects and each toxin produces different behavioural and physiological misconduct in an exposed individual. Heavy metals have bioimportance as trace element but the biotoxic effects of many of them in human biochemistry are of great concern. Hence, there is a need for understanding of the conditions such as concentration and oxidation states which make them harmful and how biotoxicity occurs. Nickel nitrate affects body physiology following its absorption through food, water and air. Predetermined doses of nickel nitrate (Ni(NO3)2] in acute (1d) and subacute (7, 14, 21, 28ds) treatments revealed significant increase in total leucocyte count (TLC). The results indicate extent of toxicity and enhancement in total leucocyte count under toxic stress of nickel nitrate in albino rat.

Downloads

Download data is not yet available.

References

ATSDR (1997). Toxicological profile for nickel (update). Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA.

Barceloux, D.G. (1999). Nickel. J. Toxicol. Clin. Toxicol., 37(2): 239–258. https://doi.org/10.1081/clt-100102423.

Blumenreich, M.S. (1990). The white blood cell and differential count. In: Walker, H.K., Hall, W.D. & Hurst, J.W. (eds.), Clinical methods: The history, physical and laboratory examinations, 3rd ed., Butterworth, Boston, MA. Chapter 153.

Finney, D.J. (1971). Probit analysis. 3rd ed., Cambridge University Press, Cambridge. pp. 333.

Flyvholm, M.A., Nielsen, G.D. & Andersen, A. (1984). Nickel content of food and estimation of dietary intake. Z. Lebensm. Unters. Forsch., 179(6): 427–431. https://doi.org/10.1007/BF01043419.

Roberts, J.R. (1999). Metal toxicity in children. In: Training Manual on Pediatric Environmental Health: Putting It into Practice. Children’s Environmental Health Network, Emeryville, CA.

Wintrobe, M.M. (1981). Clinical Hematology. 8th ed., Lea and Febiger, Philadelphia.

Downloads

Abstract views: 53 / PDF downloads: 29

Published

2018-10-06

How to Cite

Yadav, R., Singh, P. K., & Upadhyay, N. (2018). Toxicity Assessment of Nickel Nitrate and Effect on Total Leucocyte Count in Albino Rat. Advances in BioScience, 9(4), 103–105. Retrieved from https://journals.sospublication.co.in/ab/article/view/252

Issue

Vol. 9 No. 4 (2018): October

Section

Articles

License

Copyright (c) 2018 The author(s) retains the copyright of this article.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.