The Effect of Sulfated Glycosaminoglycans Extracted from Acanthaster planci on Full Thickness Excision Wound Healing in Animal Model


  • Nur Afiqah Bahrom Biomedical Sciences Department, School of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
  • K. N. S. Sirajudeen Chemical Pathology Department, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
  • George W. Yip Yong Loo Lin School of Medicine, National University of Singapore, MD10, 4 Medical Drive, 117597, Singapore.
  • Farid C. Ghazali Biomedical Sciences Department, School of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.


Sulfated Glycosaminoglycans, Acanthaster planci, Starfish, Microscopy, Wound healing


In this study, sulfated glycosaminoglycans (GAGs) was extracted from Acanthaster planci and its wound healing effects was assessed. Macroscopic examination revealed significant (p<0.05) contraction percentage (%) of wound on each observation (Day 1, Day 6 and Day 12) as compared to control group. Microscopic evaluations using light microscope, scanning, and transmission electron microscope showed that sulfated GAGs from A. planci enhanced epithelial cells migration and fibroblasts proliferation, and stimulate dense organisation of collagen fibers on the 12th day of observation, significantly (p<0.05) compared to control group. The microscopic study concluded that the second-intention excisional wound healing occurs faster in the GAGs treated group as compared to the saline-treated control group, while microscopical study using light microscope, scanning and transmission electron microscope revealed that the GAGs treated group have a significant effect in enhanced epithelization formation, fibroblasts proliferation and collagen fibers organization parameters as compared to the control group.


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Bahrom, N. A., Sirajudeen, K. N. S., Yip, G. W., & Ghazali, F. C. (2016). The Effect of Sulfated Glycosaminoglycans Extracted from Acanthaster planci on Full Thickness Excision Wound Healing in Animal Model. Advances in BioScience, 7(1), 1–7. Retrieved from




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