Antidiabetic Effects of Momordica charantia (Karela) in Male long Evans Rat

Authors

  • Md. Alamgir Z. Chowdhury Agrochemical and Environmental Research Division, Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Ganakbari, Savar, Dhaka-1000, Bangladesh.
  • M. Ibrahim Hossain Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
  • Md. Sabir Hossain Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
  • Sohel Ahmed Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
  • Tanzila Afrin Department of Pharmacy, East-West University, Aftab Nagar, Dhaka-1219, Bangladesh.
  • Nurul Karim Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.

Keywords:

Momordica charantia, Antidiabetic effect, Streptozotocin, Hexose monophosphate shunt

Abstract

The hypoglycemic effect of Momordica charantia (Karela) has been reported from many laboratories. To our knowledge, the underlying biochemical mechanism of action of this important clinical effect has not been reported. During the course of investigation of this aspect of the herbal fruit, it was reported from our laboratory that ethanolic extract of Momordica charantia suppressed gluconeogenesis in normal and streptozotocin (STZ) induced diabetic rats by depressing the hepatic gluconeogenic enzymes fructose-1,6-bisphosphatase and glucose-6-phosphatase. The herbal extract had also enhanced the activity of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of hexose monophosphate shunt (a pathway for the oxidation of glucose).

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References

Hossain, M.Z. (2003). People’s awareness about medicinal values of plants and prospect in Bangladesh. BRAC. Research and Evaluation division, Dhaka, Bangladesh.

Srivastava, J., Lambert, J. & Vietmeyer, N. (1996). Medicinal Plants: An Expanding Role in Development. World Bank - Technical Papers 320.

Fatope, M.O., Takeda, Y., Yamashita, H., Okabe, H. & Yamauchi, T. (1990). New Cucurbitane Triterpenoids from Momordica charantia. J. Nat. Prod., 53(6): 1491–1497. https://doi.org/10.1021/np50072a014.

Begum, S., Ahmed, M., Siddiqui, B.S., Khan, A., Saify, Z.S. & Arif, M. (1997). Triterpenes, A sterol and A monocyclic alcohol from Momordica charantia. Phytochemistry, 44(7): 1313–1320. https://doi.org/10.1016/S0031-9422(96)00615-2.

Okabe, H., Miyahara, Y. & Yamauchi, T. (1982). Studies on the Constituents of Momordica charantia L. IV. Characterization of the New Cucurbitacin Glycosides of the Immature Fruits. (2) Structures of the Bitter Glycosides, Momordicosides K and L. Chem. Pharm. Bull., 30(12): 4334–4340. https://doi.org/10.1016/10.1248/cpb.30.4334.

Kimura, Y., Akihisa, T., Yuasa, N., Ukiya, M., Suzuki, T., Toriyama, M., Motohashi, S. & Tokuda, H. (2005). Cucurbitane-Type Triterpenoids from the Fruit of Momordica charantia. J. Nat. Prod., 68(5): 807–809. https://doi.org/10.1021/np040218p.

Chang, C.-I., Chen, C.-R., Liao, Y.-W., Cheng, H.-L., Chen, Y.-C. & Chou, C.-H. (2008). Cucurbitane-Type Triterpenoids from the Stems of Momordica charantia. J. Nat. Prod., 71(8): 1327–1330. https://doi.org/10.1021/np070532u.

Akihisa, T., Higo, N., Tokuda, H., Ukiya, M., Akazawa, H., Tochigi, Y., Kimura, Y., Suzuki, T. & Nishino, H. (2007). Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects. J. Nat. Prod., 70(8): 1233–1239. https://doi.org/10.1021/np068075p.

Ortigao, M. & Better, M. (1992). Momordin II, a ribosome inactivating protein from Momordica balsamina , is homologous to other plant proteins. Nucleic Acids Res., 20(17): 4662–4662. https://doi.org/10.1093/nar/20.17.4662.

Lolitkar, M.M. & Rajarama Rao, M.R. (1962). Note on a Hypoglycaemic Principle Isolated from the fruits of Momordica charantia. J. Univ. Bombay, 29: 223–224.

Visarata, N. & Ungsurungsie, M. (1981). Extracts from Momordica charantia L. Quart. J. Crude Drug Res., 19(2-3): 75–80. https://doi.org/10.3109/13880208109070580.

Sridhar, M.G., Vinayagamoorthi, R., Arul Suyambunathan, V., Bobby, Z. & Selvaraj, N. (2008). Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br. J. Nutr., 99(4): 806–812. https://doi.org/10.1017/S000711450783176X.

"Ampalaya tablets out soon for diabetics". GMA News. TV. (March 27, 2007). http://www.gmanews.tv/story/35962/Ampalaya-tablets-out-soon-for-diabetics. Retrieved August 12, 2010.

Krawinkel, M.B. & Keding, G.B. (2006). Bitter gourd (Momordica Charantia): A dietary approach to hyperglycemia. Nutr Rev., 64(7 Pt 1): 331–337. https://doi.org/10.1301/nr.2006.jul.331-337.

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Published

2012-07-01

How to Cite

Chowdhury, M. A. Z., Hossain, M. I., Hossain, M. S., Ahmed, S., Afrin, T., & Karim, N. (2012). Antidiabetic Effects of Momordica charantia (Karela) in Male long Evans Rat. Advances in BioScience, 3(3), 175–180. Retrieved from https://journals.sospublication.co.in/ab/article/view/91

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Vol. 3 No. 3 (2012): July

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