Histopathological Study of Subacute Toxic Effects of Chloroacetic Acid on Albino Rats and its Correlation with Serum Levels of Malondialdehyde

Authors

  • Md. Shadab Raheel Department of Forensic Medicine, J.N. Medical College, A.M.U., Aligarh-202001, India.
  • Shamim J. Rizvi Department of Forensic Medicine, J.N. Medical College, A.M.U., Aligarh-202001, India.
  • Rana K. Sherwani Department of Pathology, J.N. Medical College, A.M.U., Aligarh-202001, India.
  • Kafil Akhtar Department of Pathology, J.N. Medical College, A.M.U., Aligarh-202001, India.
  • M. Faisal Ali Siddiqui Interdisciplinary Brain Research Centre, J.N. Medical College, A.M.U., Aligarh-202001, India.

Keywords:

Chloroacetic acid, Histopathology, Rattus norvegicus, MDA

Abstract

Human beings are increasingly being exposed to chloroacetic acid (CAA), a type of halo acetic acid. It would not be an exaggeration to say that almost the whole humankind today is affected by it or its metabolites. The concern over the carcinogenicity of haloacetic acids led the United States Environmental Protection Agency to regulate the allowable concentration of haloacetic acids in drinking water as part of the Disinfectants and Disinfection Byproducts Rule promulgated in 1998. Keeping this view in mind, the present study on histolopathological evaluation of different types of tissues viz., brain, kidney, liver, spleen and testes of Rattus norvegicus was performed, to find out the subacute toxicity of chloroacetic acid and correlation between CAA administration and changes in malondialdehyde (MDA) level in blood.

Downloads

Download data is not yet available.

References

Hanson, M.L., Sibley, P.K., Ellis, D.A., Mabury, S.A., Muir, D.C.G. & Solomon, K.R. (2002). Evaluation of monochloroacetic acid (MCA) degradation and toxicity to Lemna gibba, Myriophyllum spicatum, and Myriophyllum sibiricum in aquatic microcosms. Aquat. Toxicol., 61(3): 251–273. https://doi.org/10.1016/S0166-445X(02)00089-9.

Berg, M., Müller, S.R., Mühlemann, J., Wiedmer, A. & Schwarzenbach, R.P. (2000). Concentrations and Mass Fluxes of Chloroacetic Acids and Trifluoroacetic Acid in Rain and Natural Waters in Switzerland. Environ. Sci. Technol., 34(13): 2675–2683. https://doi.org/10.1021/es990855f.

Frank, H., Scholl, H., Renschen, D., Rether, B., Laouedj, A. & Norokorpi, Y. (1994). Haloacetic acids, phytotoxic secondary air pollutants. Environ. Sci. Pollut. Res., 1(1): 4–14. https://doi.org/10.1007/BF02986917.

Urbansky, E.T. (2001). The Fate of the Haloacetates in Drinking Water - Chemical Kinetics in Aqueous Solution. Chem. Rev., 101(11): 3233–3244. https://doi.org/10.1021/cr000883c.

Zeldenrust, J. (1951). A case of peracute poisoning by monochloracetic acid. Arch. Belg. Med. Soc., 9(1): 19-22.

Pereira, M.A. (1996). Carcinogenic Activity of Dichloroacetic Acid and Trichloroacetic Acid in the Liver of Female B6C3F1 Mice. Toxicol. Sci., 31(2): 192–199. https://doi.org/10.1093/toxsci/31.2.192.

Tominaga, M., Dote, T., Usuda, K., Shimizu, H., Toshina, Y. & Kono, K. (2003). Acute Toxicity after Monochloroacetic Acid Exposure in Rats. Bulletin of the Osaka Medical College. Osaka, Japan, 49: 11-16.

Toshina, Y., Dote, T., Usuda, K., Shimizu, H., Tominaga, M. & Kono, K. (2004). Hepatic injury and gluconeogenesis after subcutaneous injection of monochloroacetic acid in rats. Environ. Health Prev. Med., 9(2): 58–62. https://doi.org/10.1007/BF02897933.

Demir, H. & Çelik, İ. (2006). Acute Effects of Trichloroacetic acid on Serum Enzyme Levels and Erythrocyte Carbonic Anhydrase Activity in Rats. Turk. J. Biol., 30(3): 121-125.

Kulling, P., Andersson, H., Boström, K., Johansson, L.A., Lindström, B. & Nyström, B. (1992). Fatal systemic poisoning after skin exposure to monochloroacetic acid. J. Toxicol. Clin. Toxicol., 30(4): 643–652. https://doi.org/10.3109/15563659209017948.

Downloads

Abstract views: 36 / PDF downloads: 16

Published

2012-04-01

How to Cite

Raheel, M. S., Rizvi, S. J., Sherwani, R. K., Akhtar, K., & Siddiqui, M. F. A. (2012). Histopathological Study of Subacute Toxic Effects of Chloroacetic Acid on Albino Rats and its Correlation with Serum Levels of Malondialdehyde. Advances in BioScience, 3(2), 50–53. Retrieved from https://journals.sospublication.co.in/ab/article/view/80

Issue

Vol. 3 No. 2 (2012): April

Section

Articles

License

Copyright (c) 2012 The author(s) retains the copyright of this article.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Most read articles by the same author(s)